An HIV Feedback Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer
نویسندگان
چکیده
منابع مشابه
An HIV Feedback Resistor: Auto-Regulatory Circuit Deactivator and Noise Buffer
Animal viruses (e.g., lentiviruses and herpesviruses) use transcriptional positive feedback (i.e., transactivation) to regulate their gene expression. But positive-feedback circuits are inherently unstable when turned off, which presents a particular dilemma for latent viruses that lack transcriptional repressor motifs. Here we show that a dissipative feedback resistor, composed of enzymatic in...
متن کاملAn Improved Active Inductor with Tunable Active Resistor Feedback and Multi-regulated Cascode Circuit
The improvement of a conventional Gyrator-C active inductor consisting of common-emitter configured and common-collector configured with resistance feedback is presented. The fixed passive resistor is replaced with tunable active resistor (TAR) to enhance the adjustability of the active inductor. Multi-regulated Cascode (MRC) circuit is applied to boost quality factor Q. Compared with the conve...
متن کاملExternal noise and feedback regulation: steady-state statistics of auto-regulatory genetic network.
The steady-state statistics of a single gene auto-regulatory genetic network with the additive external Gaussian white noises is investigated. The main result shows that the negative feedback will result in that the mRNA noise has a positive contribution to the protein noise, but the positive feedback will result in that the mRNA noise has a negative contribution to the protein noise. If there ...
متن کاملA Simple Feedback Resistor Switch Keeps Latent HIV from Awakening
0003 Upon entering a cell, a virus often becomes dormant, turning off its genes and laying low until awakened by some trigger from its environment. When that trigger is pulled, the virus quickly ramps up production of proteins through built-in positive-feedback loops that turn up gene transcription. (In positive feedback, production of something stimulates more production of that thing, resulti...
متن کاملNoise effect on persistence of memory in a positive-feedback gene regulatory circuit.
Feedback circuits are important building blocks of gene regulatory network. Recent studies with simplified models found the advantage of coupled fast and slow feedback loops in creating bistable switch, and interlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memory. Based on the same feedback structure and mathematical model, the effect of noise on pe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Biology
سال: 2006
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0050009